Bone morphogenetic proteins and inner ear development
نویسندگان
چکیده
منابع مشابه
Regulating bone growth and development with bone morphogenetic proteins.
There are many gene products reported to promote osteoblast differentiation and thus increase bone formation, but only the transcription factor Runx2 and members of the bone morphogenetic protein (BMP) family of growth/differentiation factors have been shown to be absolute requirements for osteogenesis. Mice lacking the transcription factor Runx2 (also known as cbfa1) develop no bone. Similarly...
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Loss of neurosensory cells of the ear, caused by genetic and non-genetic factors, is becoming an increasing problem as people age, resulting in deafness and vestibular disorders. Unveiling useful mechanisms of cell cycle regulation may offer the possibility to generate new cells out of remaining ones, thus providing the cellular basis to induce new hair cell differentiation in the mammalian ear...
متن کاملPdf bone morphogenetic proteins
Human bmp-2 ELISA Kit Bmp2 recombinant antibodyAbstract. Bone morphogenetic proteins BMPs are multi-functional growth factors belonging to the transforming growth factor ß superfamily. Family members are.ABSTRACT. The BMPs bone morphogenetic proteins are a group of related proteins originally identified by their presence in bone-inductive extracts of de.Molecular cloning of bone morphogenetic p...
متن کاملOverview of bone morphogenetic proteins.
STUDY DESIGN A literature review was conducted. OBJECTIVES To review the discovery of the bone morphogenetic proteins and describe the bone morphogenetic protein products that will or may be available for clinical use. SUMMARY OF BACKGROUND DATA Bone morphogenetic proteins comprise the osteoinductive component of several tissue engineering products in late-stage development as replacements ...
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A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to regulate limb and ...
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ژورنال
عنوان ژورنال: Journal of Zhejiang University-SCIENCE B
سال: 2018
ISSN: 1673-1581,1862-1783
DOI: 10.1631/jzus.b1800084